ISG15 fast-tracks DNA replication

Energetic Electron Tracks and DNA Strand Breaks

A theoretical model with no adjustable parameters is presented to evaluate the strand break yields for incident electrons between 100 eV and I MeV. Indirect mechanisms as well as direct mechanisms are included for the production of strand breaks. The model includes the following features: (i) multiple scattering of low energy electrons; (ii) decay of hydroxyl radicals in an aqueous solution con...

RNA travel: tracks from DNA to cytoplasm.

Is There a Spatial Component to Nuclear RNA Processing and Transport? A controversial model holds that the RNA processing machinery resides at defined locations in the nucleus and that RNA transcripts travel on defined paths through these sites on their route to the cytoplasm. Thus, transcription, processing, and transport into the cytoplasm would occur in an ordered fashion as transcripts move...

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage

The Mus81 endonuclease resolves recombination intermediates and mediates cellular responses to exogenous replicative stress. Here, we show that Mus81 also regulates the rate of DNA replication during normal growth by promoting replication fork progression while reducing the frequency of replication initiation events. In the absence of Mus81 endonuclease activity, DNA synthesis is slowed and rep...

DNA replication.

Fast Reconciliations in Fluid Replication

Mobile users can increasingly depend on high speed connectivity. Despite this, using distributed file services across the wide area is painful. Past approaches sacrifice one or more of safety, visibility, and consistency in the name of performance. Instead, we propose Fluid Replication, the ability to create replicas where and when needed. These replicas, called WayStations, maintain consistenc...